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A little bit of perinatal neuropathology…
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1. Question
The structures indicated on the left panel are positive for the immunostain on the right, which is most likely:
Correct
The answer to this week’s questions is D) Alpha-synuclein. The structure shown is a Lewy body (or rather, three of them) in a pigmented neuron (in this case locus ceruleus, but could also be substantia nigra). For further details, please see the powerpoint. Thanks! Marco
Parkinson’s disease and Dementia with Lewy Bodies are probably ends of the same spectrum, both show Lewy bodies but the distribution is different.
Multi-system atrophy is the other big synucleinopathy, it classically shows glial cytoplasmic inclusions made of alpha-synuclein not Lewy bodies
A) Tau – seen in tangles (Alzheimer’s)
B) Beta-amyloid – seen in plaques (Alzheimer’s)
C) TDP-43 – seen in some kinds of fronto-temporal dementia (FTLD) and in ALS.
D) Alpha-synuclein
E) Thioflavin – a fluorescent stain that highlights both plaques and tangles, similar in
use to the Bielschowsky (silver) stain we have here.Incorrect
The answer to this week’s questions is D) Alpha-synuclein. The structure shown is a Lewy body (or rather, three of them) in a pigmented neuron (in this case locus ceruleus, but could also be substantia nigra). For further details, please see the powerpoint. Thanks! Marco
Parkinson’s disease and Dementia with Lewy Bodies are probably ends of the same spectrum, both show Lewy bodies but the distribution is different.
Multi-system atrophy is the other big synucleinopathy, it classically shows glial cytoplasmic inclusions made of alpha-synuclein not Lewy bodies
A) Tau – seen in tangles (Alzheimer’s)
B) Beta-amyloid – seen in plaques (Alzheimer’s)
C) TDP-43 – seen in some kinds of fronto-temporal dementia (FTLD) and in ALS.
D) Alpha-synuclein
E) Thioflavin – a fluorescent stain that highlights both plaques and tangles, similar in
use to the Bielschowsky (silver) stain we have here.