Cervical Lymphadenopathy

CLINICAL HISTORY
53/F presented with multiple enlarged cervical lymph nodes. Biopsy of the lymph node shown in images. Immunohistochemical/flowcytometric analysis revealed the following phenotype:

ANTIBODYRESULTCOMMENTS
CD3Negative
CD20PositiveDim
CD10/CALLAPositiveDim
CD30Negative
BCL-2PositiveDiffuse strong
BCL-6PositiveFocal
Cyclin-D1Negative
Ki-67:MIB-1>80%
MUM1/IRF4Positive
CD138 (Syndecan-1)Negative
CD45:LCAPositive
CD79aPositive
PAX-5Positive
Epithelial Membrane AntigenNegative
CK-AE1/3 CocktailNegative
CAM5.2Negative

MOLECULAR GENETICS SHOWED:

PROBE# NUCLEI EXAMINED% POSITIVE NUCLEI% CONTROL
8q24(MYC) 20077.00-3.8
IGH/MYC/CEP8 t(8;14) 20081.00-3.4

PHOTOMICROGRAPHS:

 

Figures 1 & 2: Low power views of lymph node showing effacement of architecture with diffuse and follicular infiltrate of atypical lymphoid cells.

Figures 3 & 4: Medium and high power views of lymph node showing a monotonous population of medium to large sized cells with round to oval nuclei, 1-3 prominent nucleoli and scanty blue cytoplasm. There are numerous mitoses and apoptotic activity.

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